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MeasurementsLatency measurements represent an average response from measurements gathered using JMeter. Source code from the original article can be downloaded from the following url: The rest of the test configuration is as follows. ![]() ICEfaces supports DOM compression using Fast Infoset XML compression to reduce server-side memory use between requests, so you can see the comparative trade off between memory and computation. We also took the liberty of testing two different configurations of ICEfaces related to maintaining the state of the server-side DOM. This ensures that the ICEfaces framework only maintains one unique view for each simulated test client. Test Configuration - CorrectedIn order to conduct the tests properly we worked with the ICEfaces 1.8.1 release, and set concurrentDOMviews="false" to compensate for the missing onunload() events. This is the root cause of the erroneous results originally reported. The original test configuration for ICEfaces was concurrentDOMviews="true", but under the test conditions every GET request created a new view that would consume resources for the duration of the test, as the necessary onunload() events never occurred. ICEfaces includes a feature called Concurrent DOM Views that supports opening multiple windows or tabs onto the same ICEfaces application, maintaining independent state for each view, and sharing a single Ajax Push connection between all views. The problem is compounded by misconfiguration of ICEfaces for this type of test. ICEfaces includes logic to clean up resources related to window onunload() events that should occur with each page refresh, but the test methodology did not account for this. If a simulated browser simply sends a series of GET requests, while neglecting to send messages generated for window onunload(), it appears to the Ajax framework as if the user has opened, and expects to interact with, a great many separate browser windows. This allows the load test to complete more rapidly, but if you are load testing a production application this would not be a recommended approach, as it does not simulate realistic delays between user requests.ĭespite the limitations and lack of scope existing in these tests, they do exercise the initial page load characteristics of the framework, provided that they properly simulate real-world client interaction with the application. Furthermore, because the simulated clients interact with the server so frequently, more working memory is required in the heap than may be necessary to handle a real-world load. The heap measurement is likely similar to steady-state heap use under the number of simulated users, but it does not take into account different memory use patterns during Ajax interaction or input processing. For this reason, the latency measurement in this test should be interpreted as the latency of the initial page view under load, not as typical interaction latency. Strictly speaking, this test does not exercise the Ajax functionality of the various Ajax frameworks, since the majority of Ajax interaction does not take place via full-page refresh. Problems With the TestsAll three tests follow a similar methodology that involves loading the system by repeatedly refreshing a page in the application under a variable number of simulated users. The author of the original article was negligent in his application of the test methodology to ICEfaces, and published completely erroneous results for the ICEfaces framework. ![]() The purpose of this article is to present accurate performance results for the ICEfaces RIA framework, correcting gross errors originally published in the article Performance Report of Server Side RIA Frameworks. ![]() The Premier League declined to comment to ESPN when contacted to explain how they had done this. "The Premier League, Newcastle United Football Club and St James Holdings Limited have today settled the dispute over the takeover of the club by the consortium of PIF, PCP Capital Partners and RB Sports & Media," a Premier League statement said. "Following the completion of the Premier League's Owners' and Directors' Test, the club has been sold to the consortium with immediate effect. 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It is not pronounced bow-key, boker, boka or any of the other ways you may have heard it said.ĭifferent lenses produce different out of focus effects. Photo by Renato Abati from Pexels How Do You Say the Word Bokeh?įirst of all, the word bokeh is pronounced boh-kay: bo as in “bone,” but a little shorter keh like the Spanish “que” or the letter K. the following are some photos to illustrate the shape of swirly bokeh. Generally speaking, smooth and swirly bokeh is considered more desirable than a busy and complicated bokeh. In the context of photography, it refers to the way in which out of focus areas of an image are rendered by a lens.Īs you may have noticed, some lenses will blur a background very smoothly, perhaps even producing a swirly effect, while others tend to render out of focus details in a busier way, with harder edges. What Does Bokeh Mean?īokeh comes from the Japanese word “bokeru,” meaning blur or haziness. What is a swirly bokeh lens, and when and how would you use one? Our definitive guide to swirly bokeh answers all. ![]() And of course – all the images belong to Blizzard, I just upscaled/resized/cropped them. If you need any of the wallpapers in a different resolution you can ask in the comments and I’ll try to do it.īig shoutout to the artists who created those amazing pieces. All of the wallpapers are in 1920 x 1080 resolution (or 1080 x 1920 for mobile) – I would love to make them bigger, like 4k or at least 1440p, but it was already difficult to get some images to the Full HD size. Still, I managed to create almost 100 wallpapers with an even split – 48 for mobile & 48 for desktop. Some of them couldn’t be saved (really low resolution or some jpeg artifacts that looked very poorly after upscaling), and a lot of amazing artwork is nowhere to be found. It’s much harder to find them now (usually when artists themselves are posting them online), not to mention that they often come in low resolution so they needed to be upscaled (with a filter or two applied so they don’t look bad). The reason why I haven’t done it like I did previously is because for a while now, Blizzard isn’t sharing a lot of their official card artwork, and most of the wallpapers are based on that. First I made Descent of Dragons (+Galakrond’s Awakening) ones, while Ashes of Outland should come out soon. Yep – we’re finally catching up! I’ve been asked to make wallpapers for the latest sets multiple times, so I’ve decide to finally take care of it. Could possibly be substituted for Mario’s pipes too. Import code: 0 P c 1 t 3 o 1 f 0 0t 6 0l 20 0o 13 0a 1 0f 0 1t 9 1l 4 1o 9 1a 1 1m 0 1f 0įrom the infamous mobile game, here’s a slightly unwieldy crosshair made from the trademark green pipes. Make it your own and edit the opacity and other settings, too. Easily used, and yet still fun and creative. Naruto fans, maybe we’ve found the one for you. Modeled after Reyna’s (Valorant’s very own) non-Ultimate abillity, Leer, the Reyna Flash is a little more complicated than most crosshairs. Import code: 0 P c 7 o 1 d 1 f 0 0t 10 0l 5 0o 0 0a 1 0f 0 1t 6 1l 1 1o 5 1a 0 1m 0 1f 0Ī crossover crosshair? This one’s fairly obvious what it is just by looking at it, with a two tone color scheme, but no additional features. Import code: 0 P c 6 t 3 o 0.25 d 1 z 3 a 0.5 f 0 m 1 0t 1 0l 17 0o 20 0a 1 0m 1 1t 9 1l 7 1o 15 1a 0.5 1m 0įor those players that like a bigger crosshair, this will give you a decent amount of vision, despite its size due to the opacity. This crosshair has “Fade Crosshair With Firing Error” enabled, and when firing, Steve’s head will disappear. Need we say more? There’s plenty of crosshairs that take advantage of famous and instantly recognisable shapes and characters. This crosshair has “Fade Crosshair With Firing Error” enabled. Glasses is a fun little crosshair that doesn’t have too many extraneous parts that it’s too hard to play with. If you’re looking for our pick for the most accurate ones used by Twitch streamers and pro-gamers, read on. Straight from Valorant Crosshair Database, these are our pick for the ten coolest looking crosshairs in Valorant. Valorant to Overwatch 2 sens converter – what sensitivity is best? Top 10 coolest crosshairs in Valorant Within this list, we’ll be not only looking at which ones look the best, but some of the best performing ones for Twitch streamers and Esports players, too. ![]() Check out this list of the top 10 coolest Valorant crosshairs. The default Volarant crosshair is effective, yet it’s clearly not the best out there, and there’s quite a lot of choice. If you’re looking for the best Gaming Mouse for Valorant in 2023, check that out too. Mouse sensitivity goes hand in hand with crosshairs, and Valorant has some great ones for you to choose from. Messing around with the in-game setting of any shooter is usually a right of passage for any competitive player, and the crosshair is no exception. ![]() Chronic inflammation hampers iron absorption from the diet and causes iron retention in reticuloendothelial cells, which results in insufficient iron availability to meet the body’s needs. ![]() Remarkably, iron deficiency is diagnosed in more than half of patients afflicted with colorectal, lung, and pancreatic cancers, which are also associated with high prevalence of cachexia (Ludwig et al, 2013). In cancer cachexia, systemic alterations contribute to the uncontrollable decrease in quality of life, insulin resistance, liver dysfunction, chronic inflammation, and even altered gut microbiota and nutrient absorption (Porporato, 2016). Indeed, the prevalence of cachexia reaches 80% in advanced-stage cancer patients and has been estimated to directly cause at least 20% of all cancer-related deaths (Tisdale, 2002). Massive skeletal muscle atrophy is the hallmark of a multi-organ wasting disorder known as cachexia, which causes severe asthenia and intolerance to therapies in patients with chronic diseases such as cardiac failure, COPD, and notably cancer, leading to poor clinical outcomes (Fearon et al, 2011 Porporato, 2016). In healthy humans, skeletal muscle makes up to 40% of the total body mass (Janssen et al, 2000), of which 20% are constituted by proteins. Overall, our findings provide new mechanistic insights in cancer-induced skeletal muscle wasting, and support targeting iron metabolism as a potential therapeutic option for muscle wasting diseases. Importantly, iron supplementation refuels mitochondrial oxidative metabolism and energy production. Furthermore, iron supplementation was sufficient to preserve both muscle function and mass, prolong survival in tumor-bearing mice, and even rescues strength in human subjects within an unexpectedly short time frame. We found that modulation of iron levels directly influences myotube size in vitro and muscle mass in otherwise healthy mice. In this study, we discovered strong alterations of iron metabolism in the skeletal muscle of both cancer patients and tumor-bearing mice, characterized by decreased iron availability in mitochondria. Knowledge regarding the mechanism of cancer-induced cachexia remains very scarce, making cachexia an unmet medical need. Tel: +39 0116706422 E-mail: Ĭachexia is a wasting syndrome characterized by devastating skeletal muscle atrophy that dramatically increases mortality in various diseases, most notably in cancer patients with a penetrance of up to 80%. These authors contributed equally to this work as senior authors These authors contributed equally to this work as first authors 10 Center for Oncological Research (CORE), Integrated Personalized and Precision Oncology Network (IPPON), University of Antwerp, Antwerp, Belgium.9 Department of Medical Oncology, University Hospital Antwerp, Edegem, Belgium.8 Laboratory of Tumor Inflammation and Angiogenesis, Department of Oncology, Katholieke Universiteit Leuven (KUL), Leuven, Belgium.7 Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology (CCB), Vlaams Instituut voor Biotechnologie (VIB), Leuven, Belgium.6 Department of Life Sciences and System Biology, University of Torino, Turin, Italy.5 Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université catholique de Louvain (UCLouvain), Brussels, Belgium.4 Department of Clinical and Biological Sciences, University of Torino, Turin, Italy.3 Department of Surgical, Oncological and Gastroenterological Sciences, Padova University Hospital, Padova, Italy.2 Department of Biomedical Sciences, University of Padova, Padova, Italy.1 Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Turin, Italy. |